Primary tabs
Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | Dosing |
|---|---|
| All IV Indications | 5 mg/kg IV x1 loading dose, then contact ID pharmacy for maintenance dose recommendations |
ZSFG: Non-formulary
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
|---|---|---|
| All IV Indications | 5 mg/kg IV x1 loading dose, then contact ID pharmacy for dosing recommendations | |
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.
Dosing for inhaled colistin per primary team protocols
Other more effective, less-toxic agents are available for most serious Gram-negative rod infections. In cases where an IV polymyxin is necessary, polymyxin B should be used preferentially for non-urinary tract infections in adults.
Restricted to ID or Antimicrobial Stewardship
*Inhaled use of colistin is allowed for unrestricted use in prophylaxis in lung transplant.