Ceftaroline

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl >50 mL/min 30-50 mL/min 15-30 mL/min <15 mlL/min
Skin/Soft Tissue Infections or Community-acquired Pneumonia with low MRSA risk 600 mg IV q12h 400 mg IV q12h 300 mg IV q12h 200 mg IV q12h
Severe Infections, Pneumonia with documented or suspected MRSA 600 mg IV q8h 600 mg IV q12h 400 mg IV q12h 300 mg IV q12h

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication

Intermittent Hemodialysis

Continuous Hemodialysis
Skin/Soft Tissue Infections or Community-acquired Pneumonia with low MRSA risk 200 mg IV q12h 400 mg IV q12h
Severe Infections, Pneumonia with documented or suspected MRSA 300 mg IV q12h 600 mg IV q12h

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.

All use requires authorization from the Antimicrobial Stewardship Program or consulting ID fellow

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