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Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | CrCl > 50 mL/min | 30-50 mL/min | 15-30 mL/min | < 15 mL/min |
|---|---|---|---|---|
| Skin/Soft Tissue Infections or Community-acquired Pneumonia with low MRSA risk | 600 mg IV q12h | 400 mg IV q12h | 300 mg IV q12h | 200 mg IV q12h |
| Severe Infections, Pneumonia with documented or suspected MRSA | 600 mg IV q8h | 400 mg IV q8h | 300 mg IV q8h | 200 mg IV q8h |
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
|---|---|---|
| Skin/Soft Tissue Infections or Community-acquired Pneumonia with low MRSA risk | 200 mg IV q12h | 400 mg IV q12h |
| Severe Infections, Pneumonia with documented or suspected MRSA | 200 mg IV q8h | 600 mg IV q12h |
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.
Serious infections: ceftaroline dosed q12h may be an option in certain situations for CrCl < 50 mL/min and in iHD. Contact ID pharmacy for assistance.
Restricted to ID or Antimicrobial Stewardship