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Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | CrCl > 30 mL/min | 10 - 29 mL/min | < 10 mL/min |
|---|---|---|---|
| Symptomatic Enterococcus UTI | 500 mg PO q8h | 500 mg PO q12h | 500 mg PO q24h |
| Gram-negative bacteremia, other severe infections, community-acquired pneumonia (select outpatients) | 1 g PO q8h | 1 g PO q12h | 500 mg PO q12h |
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis* |
|---|---|---|
| Symptomatic Enterococcus UTI | 500 mg PO x1 now, then qPM | 500 mg PO q8h |
| Gram-negative bacteremia, other severe infections, community acquired pneumonia (select outpatients) | 500 mg PO q12h | 1 g PO q8h |
*Limited data; recommendations based upon local expert opinion
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.