Atovaquone

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication Dose  Notes 
Pneumocystis PROPHYLAXIS 1500 mg PO Q24H with food  For patients who are intolerant of sulfa 
Pneumocystis TREATMENT (mild diease) 750 mg PO Q12H with food 

For patients who are intolerant of sulfa 

Mild disease (A-a O2 gradient < 35 mmHg and PAO2 >70 mmHg)

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication Dose  Notes 
Pneumocystis PROPHYLAXIS 1500 mg PO Q24H with food  For patients who are intolerant of sulfa 
Pneumocystis TREATMENT (mild disease)  750 mg PO Q12H with food 

For patients who are intolerant of sulfa 

Mild disease  (A-a O2 gradient < 35 mmHg and PAO2 >70 mmHg)

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.

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