| Weight | PPI Dose Equivalents |
|---|---|
| 15 to 24 kg |
Esomeprazole (Nexium) 20 mg enterally twice daily OR Lansoprazole (Prevacid) 15 mg enterally twice daily OR Omeprazole (Prilosec) 20 mg enterally twice daily OR Pantoprazole (Protonix) 20 mg enterally twice daily |
| 25 to 34 kg |
Esomeprazole (Nexium) 30 mg enterally twice daily OR Lansoprazole (Prevacid) 30 mg enterally twice daily OR Omeprazole (Prilosec) 30 mg enterally twice daily OR Pantoprazole (Protonix) 40 mg enterally twice daily |
| > 35 kg |
Esomeprazole (Nexium) 40 mg enterally twice daily OR Lansoprazole (Prevacid) 30 mg enterally 2 to 3 times daily OR Omeprazole (Prilosec) 40 mg enterally twice daily OR Pantoprazole (Protonix) 40 mg or 80 mg enterally twice daily |
| Weight | PPI Dose Equivalents |
|---|---|
| 6 to < 10 kg |
Rabeprazole (Aciphex) 10 mg enterally twice daily |
| 10 to < 30 kg |
Rabeprazole (Aciphex) 15 mg enterally twice daily |
| ≥ 30 kg |
Rabeprazole (Aciphex) 20 mg enterally twice daily |
Note: Esomeprazole (Nexium®) and rabeprazole (Aciphex®) are less susceptible to degradation by rapid metabolizers with CYP2C19 genetic polymorphism, and therefore, may be preferred when available.
Rapid metabolizers are more frequent in white individuals (56%–81%) compared to individuals of Asian descent.