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Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | CrCl ≥ 50 mL/min | 30 - 49 mL/min | 10 - 29 mL/min | < 10 mL/min |
|---|---|---|---|---|
| Orolabial/genital HSV infection (initial episode) OR recurrent episode treatment in people with HIV | 1000 mg PO q12h | 1000 mg PO q12h | 1000 mg PO q24h | 500 mg PO q24h |
| Orolabial/genital HSV suppression OR recurrent episode treatment | 500 mg PO q12h | 500 mg PO q12h | 500 mg PO q24h | 500 mg PO q24h |
| Primary Varicella/Herpes Zoster Infection | 1000 mg PO q8h | 1000 mg PO q12h | 1000 mg PO q24h | 500 mg PO q24h |
| Immunocompromised Prophylaxis | 500 mg PO q12h | 500 mg PO q12h | 500 mg PO q24h | 500 mg PO q24h |
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
|---|---|---|
| HSV Infection |
500 mg PO qPM |
Insufficient data; contact ID pharmacy for more information |
| VZV Infection | ||
| Immunocompromised Prophylaxis |
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.