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Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | CrCl ≥50 mL/min | 30-49 mL/min | 10-29 mL/min | <10 mL/min |
|---|---|---|---|---|
|
Respiratory Syncytial Virus (RSV) Use total body weight for dosing |
40-49 kg = 400 mg PO q12h 50-59 kg = 400 mg PO qAM PLUS 600 mg PO qPM 60-69 kg = 600 mg PO q12h 70-79 kg = 600 mg PO qAM PLUS 800 mg PO qPM 80-89 kg = 800 mg PO q12h 90 kg or greater = 600 mg PO q8h |
40-59 kg = 200 mg PO q12h 60 kg or greater = 200 mg PO q8h |
200 mg PO daily | 200 mg PO daily (consider contacting ID/ASP pharmacist) |
| Hepatitis C | Dosing is highly individualized. Refer to www.hcvguidelines.org for detailed information on appropriate indications for ribavirin in the treatment of hepatitis C infection. | |||
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
|---|---|---|
|
Respiratory Syncytial Virus (RSV) Use total body weight for dosing |
200 mg PO daily (give daily - on days of hemodialysis, give dose afterwards) |
40-59 kg = 200 mg PO q12h 60 kg or greater = 200 mg PO q8h |
| Hepatitis C |
Dosing is highly individualized. Refer to www.hcvguidelines.org for detailed information on appropriate indications for ribavirin in the treatment of hepatitis C infection. |
|
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.
For treatment of respiratory syncytial virus (RSV) in adult patients at UCSF, refer to the RSV Treatment Guideline.