Remdesivir

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl >30 mL/min CrCl <30 mL/min
All Indications 200 mg IV x1 then 100 mg IV q24h No adjustment required; vehicle may accumulate in renal dysfunction - consider risk/benefit

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication

Intermittent Hemodialysis

Continuous Hemodialysis
All Indications 200 mg IV x1 then 100 mg IV q24h 200 mg IV x1 then 100 mg IV q24h

Dialysis Notes

Vehicle may accumulate in renal dysfunction - consider risk/benefit.

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.

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