Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | CrCl >30 mL/min | CrCl <30 mL/min |
|---|---|---|
| All Indications | 200 mg IV x1 then 100 mg IV q24h | No adjustment required; vehicle may accumulate in renal dysfunction - consider risk/benefit |
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
|---|---|---|
| All Indications | 200 mg IV x1 then 100 mg IV q24h | 200 mg IV x1 then 100 mg IV q24h |
Dialysis Notes
Vehicle may accumulate in renal dysfunction - consider risk/benefit.
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.