Pyrazinamide

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl > 30 mL/min < 30 mL/min
All Indications

20-25 mg/kg PO q24h:

45 – 54 kg: 1250mg q24h

55 – 64 kg: 1500mg q24h

66 - 75 kg: 1750mg q24h

>=76 kg: 2000mg q24h

25 – 35mg/kg PO three times weekly

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication

Intermittent Hemodialysis

Continuous Hemodialysis
All Indications 25-35 mg/kg PO x1 now and post-HD 20-25 mg/kg PO q24h

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.

Supplied as 500mg tablets