Pyrazinamide

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl > 30 mL/min < 30 mL/min
All Indications

20-25 mg/kg PO q24h:

40-55 kg: 1000mg q24h

56-75 kg: 1500mg q24h

76-90 kg: 2000mg q24h

>=90 kg: Contact ID/ID pharmacy

20-25 mg/kg PO three times weekly

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication

Intermittent Hemodialysis

Continuous Hemodialysis
All Indications 20-25 mg/kg PO x1 now and post-HD 20-25 mg/kg PO q24h

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.

Dosing in obesity (BMI > 30): use lean body weight (see online calculator).

Supplied as 500mg tablets

This dosing aligns with current practices at the SFDPH TB Clinic (as of 8/2022). For patients in other counties, contact the respective TB clinics for dosing recommendations. 

References: