Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl > 30 mL/min < 30 mL/min
All Indications

20-25 mg/kg PO q24h:

36-39 kg: 750 mg PO q24h

40-50 kg: 1000mg PO q24h

51-59 kg: 1250 mg PO q24h

60-70 kg: 1500mg PO q24h

71-80 kg: 1750 mg PO q24h

> 81 kg: 2000 mg PO q24h

25-30 mg/kg PO three times weekly

Supplied as 500 mg tablets

This dosing aligns with current practices at the SFDPH TB Clinic (as of 5/2023). For patients in other counties, contact the respective TB clinics for dosing recommendations. 

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis


Intermittent Hemodialysis

Continuous Hemodialysis
All Indications 20-25 mg/kg PO x1 now and post-HD 20-25 mg/kg PO q24h

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.