Penicillin G (IV)

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl > 50 mL/min CrCl 10 – 50 mL/min CrCl < 10 mL/min
Group B Streptococcus (GBS) Prophylaxis (until delivery)

5 million units x 1 then 

followed by 3 million units IV q4h

5 million units x 1 then 

followed by 3 million units IV q4h

5 million units x 1 then 

followed by 3 million units IV q6h

Neurosyphilis, meningitis, necrotizing SSTI, toxic shock syndrome 4 million units IV q4h 3 million units IV q4h 3 million units IV q6h
Endovascular, bacteremia 3 million units IV q4h 3 million units IV q6h 2 million units IV q6h

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication

Intermittent Hemodialysis

Continuous Hemodialysis
Group B Streptococcus (GBS) Prophylaxis (until delivery)

5 million units x 1 then 

followed by 3 million units IV q6h

5 million units x 1 then 

followed by 3 million units IV q4h

Neurosyphilis, meningitis, necrotizing SSTI, toxic shock syndrome

4 million units IV x1, then 2 million units IV q4h* 3 million units IV q4h
Endovascular, bacteremia 3 million units IV x1, then 2 million units IV q6h 3 million units IV q6h

*Penicillin G Potassium may contain clinically significant amounts of potassium; consider penicillin G sodium instead, if available.

Dialysis Notes

References: