Penicillin G

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl > 50 mL/min CrCl 10 – 50 mL/min CrCl < 10 mL/min
Neurosyphilis, meningitis 4 million units IV q4h 3 million units IV q4h 3 million units IV q6h
Endovascular, bacteremia 3 million units IV q4h 3 million units IV q6h 2 million units IV q6h
Less serious infections 3 million units IV q6h 2 million units IV q6h 1 million units IV q6h

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication

Intermittent Hemodialysis

Continuous Hemodialysis
Neurosyphilis, meningitis 2 million units IV q6h 3 million units IV q4h
Endovascular, bacteremia 2 million units IV q8h 3 million units IV q6h
Less serious infection 2 million units IV q12h 2 million units IV q6h

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.