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Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | CrCl > 60 mL/min | 31-60mL/min | 10-30mL/min |
|---|---|---|---|
| Influenza treatment | 75 mg PO BID | 30 mg PO BID | 30 mg PO daily |
| Influenza prophylaxis | 75mg PO daily | 30mg PO daily | 30mg PO every other day |
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
|---|---|---|
| Influenza treatment | 30 mg PO x1 now, then post-HD | 75 mg PO BID |
| Influenza prophylaxis | 30 mg po x1 dose per week | 30 mg po daily |
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.