Oseltamivir

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl > 60 mL/min 31-60mL/min 10-30mL/min
Influenza treatment 75 mg PO BID 30 mg PO BID 30 mg PO BID
Influenza prophylaxis 75mg PO daily 30mg PO daily 30mg PO every other day

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication

Intermittent Hemodialysis

Continuous Hemodialysis
Influenza treatment 30 mg PO x1 now, then post-HD 75 mg PO BID
Influenza prophylaxis 30 mg po x1 dose per week 30 mg po daily

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.