Nitrofurantoin (Macrobid)

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl > 60 mL/min < 60 mL/min
Cystitis Treatment 100 mg PO q12h Data limited for CrCl<60 mL/min; consider alternatives
Cystitis Prophylaxis 100 mg PO q24h

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication Intermittent Hemodialysis Continuous Hemodialysis
Cystitis Treatment

 

Data limited for dosing in hemodialysis; consider alternatives

Cystitis Prophylaxis

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.