Nafcillin

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication Dosing Notes
Meningitis, osteomyelitis or endovascular infection 2 g IV Q4h

 

No renal dose adjustment

Uncomplicated infection 1 g IV Q6h

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication Dosing Notes
Meningitis, osteomyelitis or endovascular infection 2 g IV Q4h

 

No dose adjustment in hemodialysis

Uncomplicated infection 1 g IV Q6h

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.