Fosfomycin

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl > 50 mL/min < 50 mL/min
Uncomplicated cystitis 3 g PO x 1 dose 3 g PO x 1 dose
Complicated cystitis 3 g PO every 2 days x 3 doses 3 g PO every 3 days x 3 doses

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication

Intermittent Hemodialysis

Continuous Hemodialysis
Uncomplicated cystitis 3 g PO x1 dose; administer after HD No data
Complicated cystitis 3g PO every 3 days x3 doses; administer after HD No data

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.