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Dosing: Adult Antimicrobial Dosing, Non-dialysis
Weight | CrCl > 30 mL/min | < 30 mL/min |
---|---|---|
30-40 kg | 600 mg PO q24h | 20-25 mg/kg PO three times weekly |
41-50 kg | 800 mg PO q24h | 20-25 mg/kg PO three times weekly |
51-60 kg | 1000 mg PO q24h | 20-25 mg/kg PO three times weekly |
61-70 kg | 1200 mg PO q24h | 20-25 mg/kg PO three times weekly |
71-80 kg | 1400 mg PO q24h | 20-25 mg/kg PO three times weekly |
81-90 kg | 1600 mg PO q24h | 20-25 mg/kg PO three times weekly |
> 91 kg | Consult ID or ID pharmacy | Consult ID or ID pharmacy |
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
---|---|---|
All Indications | 20-25 mg/kg PO x1 now and post-HD | 15-20 mg/kg PO q24h |
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.
Dose based on ideal body weight. Dosing in obesity (BMI > 30): use lean body weight (see online calculator).
Drug is available in 400mg and 100mg tablets.
This dosing aligns with current practices at the SFDPH TB Clinic (as of 8/2022). For patients in other counties, contact the respective TB clinics for dosing recommendations.