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Dosing: Adult Antimicrobial Dosing, Non-dialysis
This dosing aligns with current practices at the SFDPH TB Clinic (as of 5/2023) for treatment of tuberculosis. For patients in other counties, contact the respective TB clinics for dosing recommendations.
| Weight | CrCl > 30 mL/min | < 30 mL/min |
|---|---|---|
| 30-40 kg | 600 mg PO q24h | 20-25 mg/kg PO three times weekly |
| 41-50 kg | 800 mg PO q24h | 20-25 mg/kg PO three times weekly |
| 51-60 kg | 1000 mg PO q24h | 20-25 mg/kg PO three times weekly |
| 61-70 kg | 1200 mg PO q24h | 20-25 mg/kg PO three times weekly |
| 71-80 kg | 1400 mg PO q24h | 20-25 mg/kg PO three times weekly |
| 81-90 kg | 1600 mg PO q24h | 20-25 mg/kg PO three times weekly |
| > 91 kg | Consult ID or ID pharmacy | Consult ID or ID pharmacy |
Therapeutic drug monitoring may be utilized under the guidance of SF TB Clinic, ID, and/or ID/ASP Pharmacy. Higher dosing may be required.
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
|---|---|---|
| All Indications | 20-25 mg/kg PO x1 now and post-HD | 15-20 mg/kg PO q24h |
Therapeutic drug monitoring may be utilized under the guidance of SF TB Clinic, ID, and/or ID/ASP Pharmacy. Higher dosing may be required.
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.
Drug is available in 400mg and 100mg tablets.
This dosing aligns with current practices at the SFDPH TB Clinic (as of 5/2023) for treatment of tuberculosis. For patients in other counties, contact the respective TB clinics for dosing recommendations.