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Dosing: Adult Antimicrobial Dosing, Non-dialysis
This dosing aligns with current practices at the SFDPH TB Clinic (as of 5/2025) for treatment of tuberculosis. For patients in other counties, contact the respective TB clinics for dosing recommendations.
| Indication | CrCl > 30 mL/min | < 30 mL/min |
|---|---|---|
| Tuberculosis |
20 - 24 mg/kg PO daily Max starting dose = 1600 mg. For patients > 80 kg, contact ID pharmacy for dosing advice. |
20 - 24 mg/kg PO three times weekly |
|
Non-tuberculous mycobacteria (MAC) |
15 mg/kg PO daily | 15 mg/kg PO three times weekly |
Therapeutic drug monitoring may be utilized under the guidance of SF TB Clinic, ID, and/or ID/ASP Pharmacy. Higher dosing may be required.
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
|---|---|---|
| Tuberculosis | 20 - 24 mg/kg PO x 1 now and post-HD | 15-20 mg/kg PO q24h |
| Non-tuberculous mycobacteria (MAC) | 15 mg/kg PO x 1 now and post-HD | 15 mg/kg PO q24h |
Therapeutic drug monitoring may be utilized under the guidance of SF TB Clinic, ID, and/or ID/ASP Pharmacy. Higher dosing may be required.
Dialysis Notes
Drug is available in 400mg and 100mg tablets.
This dosing aligns with current practices at the SFDPH TB Clinic (as of 5/2023) for treatment of tuberculosis. For patients in other counties, contact the respective TB clinics for dosing recommendations.