Primary tabs
Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Weight | CrCl > 30 mL/min | < 30 mL/min |
|---|---|---|
| 30-40 kg | 600 mg PO q24h | 20-25 mg/kg PO three times weekly |
| 41-50 kg | 800 mg PO q24h | 20-25 mg/kg PO three times weekly |
| 51-60 kg | 1000 mg PO q24h | 20-25 mg/kg PO three times weekly |
| 61-70 kg | 1200 mg PO q24h | 20-25 mg/kg PO three times weekly |
| 71-80 kg | 1400 mg PO q24h | 20-25 mg/kg PO three times weekly |
| 81-90 kg | 1600 mg PO q24h | 20-25 mg/kg PO three times weekly |
| > 91 kg | Consult ID or ID pharmacy | Consult ID or ID pharmacy |
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
|---|---|---|
| All Indications | 20-25 mg/kg PO x1 now and post-HD | 15-20 mg/kg PO q24h |
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.
Dose based on ideal body weight. Dosing in obesity (BMI > 30): use lean body weight (see online calculator).
Drug is available in 400mg and 100mg tablets.
This dosing aligns with current practices at the SFDPH TB Clinic (as of 8/2022). For patients in other counties, contact the respective TB clinics for dosing recommendations.