Dapsone

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication Dose Notes

 Pneumocystis pneumonia (PROPHYLAXIS)

100 mg PO Q24H 

Use in patients who are intolerant of sulfa

No renal adjustment 

G6-PD screen recommended prior to initiation

Dapsone monotherapy does not provide prophylaxis for Toxoplasmosis

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication Dose Notes

 Pneumocystis pneumonia (PROPHYLAXIS)

100 mg PO Q24H 

Use in patients who are intolerant of sulfa

No renal adjustment 

G6-PD sceen recommended prior to initiation

Dapsone monotherapy does not provide prophylaxis for Toxoplasmosis

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.

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