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Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | Dose | Notes |
|---|---|---|
|
600 mg IV q8h 450 mg PO q8h |
No renal dose adjustment | |
| Necrotizing Soft Tissue Infection & Group A Streptococcus Infection, Pelvic Inflammatory Disease | 900 mg IV Q8h | No renal dose adjustment |
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
| Indication | Dose | Notes |
|---|---|---|
| Uncomplicated Infection |
600 mg IV q8h 450 mg PO q8h |
No dose adjustment in hemodialysis |
| Necrotizing Soft Tissue Infection & Group A Streptococcus Infection, Pelvic Inflammatory Disease | 900 mg IV Q8h |
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.