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Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | CrCl ≥ 30 mL/min | CrCl < 30 mL/min |
|---|---|---|
| Prophylaxis in neutropenic fever in patients who are intolerant of fluoroquinolones AND no history of ESBL/CRE organisms | 200 mg po q 12h | 200 mg po q 24h |
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
|---|---|---|
| Prophylaxis in neutropenic fever in patients who are intolerant of fluoroquinolones AND no history of ESBL/CRE organisms | 200 mg x 1 then 200 mg po daily (on days of HD, administer after HD session) | 200 mg po q12h |
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.