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Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | CrCl >50 mL/min | CrCl 30-50 mL/min | CrCl 10-29 mL/min | CrCl <10 mL/min |
|---|---|---|---|---|
| Standard dosing, NTM infection | 2 g IV q6h | 2 g IV q8h | 2 g IV q12h | 1 g IV q24h |
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
|---|---|---|
| Standard dosing, NTM infection | 1 g q24h (on days of HD, give after HD) | 2 g IV q8h* |
*Limited data exist for CRRT dosing. Consider alternative antibiotic. May dose for CrCl 30 to 50 mL/minute if necessary.
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.