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Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | CrCl > 30 mL/min | 10 - 29 mL/min | < 10 mL/min |
|---|---|---|---|
| Uncomplicated Gram-Positive Infection | 1 g IV q8h | 1 g IV q12h | 1 g IV q24h |
| Gram-Negative or Complicated Gram-Positive Infection | 2 g IV q8h | 2 g IV q12h | 1 g IV q24h |
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
|---|---|---|
| All Indications |
2 g IV x1 now and post-HD Alternative dosing for patients on stable hemodialysis schedule: 2 g IV / 2 g IV / 3 g IV post-HD 3 g given prior to 72hr intradialytic period; for example, after Friday dialysis for pts on MWF schedule |
2 g IV q12h |
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.