Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl > 30 mL/min 10 - 29 mL/min < 10 mL/min
Uncomplicated Gram-Positive Infection 1 g IV q8h 1 g IV q12h 1 g IV q24h
Gram-Negative or Complicated Gram-Positive Infection 2 g IV q8h 2 g IV q12h 1 g IV q24h

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis


Intermittent Hemodialysis

Continuous Hemodialysis
All Indications

2 g IV x1 now and post-HD

Alternative dosing for patients on stable hemodialysis schedule: 2 g IV / 2 g IV / 3 g IV post-HD

3 g given prior to 72hr intradialytic period; for example, after Friday dialysis for pts on MWF schedule

2 g IV q12h

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.