Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | CrCl > 30 mL/min | 10 - 29 mL/min | < 10 mL/min |
|---|---|---|---|
| Uncomplicated Gram-Positive Infection | 1 g IV q8h | 1 g IV q12h | 1 g IV q24h |
| Gram-Negative or Complicated Gram-Positive Infection | 2 g IV q8h* | 2 g IV q12h | 1 g IV q24h |
*Higher doses may be indicated in select patients with deep-seated MSSA infections, particularly for initial therapy and/or those with clinical instability. Discuss with ID/ASP pharmacy.
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
| Indication | Intermittent Hemodialysis | Continuous Hemodialysis |
|---|---|---|
| All Indications | 2 g IV x1 now and post-HD Alternative dosing for patients on stable hemodialysis schedule: 2 g IV / 2 g IV / 3 g IV post-HD 3 g given prior to 72hr intradialytic period; for example, after Friday dialysis for pts on MWF schedule | 2 g IV q12h |