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Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | CrCl > 25 mL/min | 10 - 25 mL/min | < 10 mL/min |
|---|---|---|---|
| Immuncompromised Prophylaxis | 400 PO q12h | 200 mg PO q 12h | 200 mg PO q 12h |
|
Orolabial/genital HSV Infection (initial episode) |
400 mg PO q8h | 400 mg PO q8h |
200 mg PO q12h |
| Genital HSV Infection (recurrent episode) | 800 mg PO q12h | 800 mg PO q12h | |
| Orolabial/genital HSV Suppression | 400 mg PO q12h | 400 mg PO q12h | |
|
VZV infection (mild) |
800 mg PO 5-times daily | 800 mg PO q8h |
400 mg PO q12h |
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis* |
|---|---|---|
| Immunocompromised prophylaxis | 200 mg po q12h | 400 mg po q 12h |
|
Orolabial/genital HSV Infection (initial episode) |
200 mg po q12h | 400 mg po q 8h |
|
Genital HSV Infection (recurrent episode) |
200 mg po q 12h | 400 mg po q 12h |
|
VZV infection (mild) |
400 mg PO q 12h | 800 mg PO 5 times a day |
*Limited data but based upon local expert opinion
Dialysis Notes
Consider supplemental dose after hemodialysis