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Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | CrCl > 25 mL/min | 10 - 25 mL/min | < 10 mL/min |
|---|---|---|---|
|
Orolabial/genital HSV Infection (initial episode) |
400 mg PO q8h | 400 mg PO q8h |
200 mg PO q12h |
| Genital HSV Infection (recurrent episode) | 800 mg PO q12h | 800 mg PO q12h | |
| Orolabial/genital HSV Suppression | 400 mg PO q12h | 400 mg PO q12h | |
| Primary Varicella/Herpes Zoster Infection | 800 mg PO 5-times daily | 800 mg PO q8h |
800 mg PO q12h |
| Indication | CrCl > 50 mL/min | 10 - 50 mL/min | < 10 mL/min |
|---|---|---|---|
|
Immunocompromised Prophyalxs |
400 mg PO BID | 200 mg PO BID |
200 mg PO daily |
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
|---|---|---|
| Immunocompromised Prophylaxis | 200 mg PO daily |
Insufficient data; contact ID pharmacy for more information |
| HSV Infection | 200 mg PO q12h | |
| VZV Infection | 800 mg PO q12h | |
| Consider supplemental dose after hemodialysis |
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.