Some studies have associated higher minimum inhibitory concentrations (MICs) in Staphylococcus aureus with an increased likelihood of therapeutic failure. (Note: to date, studies do not indicate a strong relationship between vancomycin MIC and outcomes in Staphylococcus epidermidis, where a vancomycin MIC of 2 is common).
Pediatric Inpatient Vancomycin MIC Distribution for S. aureus
| Vancomycin MIC (all S. aureus) | 2020-2022 (n=340 total) |
| 0.5 | 13 (3.8%) |
| 1 | 320 (94%) |
| 2 | 7 (2.1%) |