UCSF Benioff Children's Hospital Antimicrobial Susceptibility: Vancomycin Minimum Inhibitory Concentrations Among Staphylococcus aureus

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Some studies have associated higher minimum inhibitory concentrations (MICs) in Staphylococcus aureus with an increased likelihood of therapeutic failure. (Note: to date, studies do not indicate a strong relationship between vancomycin MIC and outcomes in Staphylococcus epidermidis, where a vancomycin MIC of 2 is common).

Pediatric Inpatient Vancomycin MIC Distribution for S. aureus

Vancomycin MIC (all S. aureus) 2015-2017
0.5 3.1% (12/392)
1 94.1% (369/392)
2 3.8% (11/392)
Vancomycin MIC (MRSA only)  
0.5 0% (0/80)
1 96.3% (77/80)
2 3.8% (3/80)