UCSF Benioff Children's Hospital Antimicrobial Susceptibility: Pediatric Inpatient/ED, Incidence-Weighted Gram-Negative Coverage By Drug

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The table below lists the % of Gram-negative organisms that tested susceptible to each listed drug or combination in 2015-2017.  The values incorporate the frequency with which the various organisms were isolated as well as their sensitivity to the drug; more commonly isolated organisms contribute more to the overall susceptibility results.  Results are based on standard methodology.

Population Number of Isolates Ceftriaxone Ceftazidime Cefepime Pip/tazo Meropenem
All inpatient/ED isolates 963 78% (89%)* 91% 96% 95% 98%
ICN  120 85% (92%)*,** 92% 97% 96% 98%
PICU & CICU  150 56% (79%)* 83% 91% 89% 97%
non-ICU  693 81% (90%)* 92% 97% 95% 99%

* Value in parenthesis is susceptibility if Pseudomonas and Acinetobacter are excluded

** For ICN, Cefotaxime susceptibility can be inferred from Ceftriaxone susceptibility; Gentamicin susceptibility among ICN Gram-negative isolates is 88% (96% if Pseudomonas and Acinetobacter are excluded)

 

Gram Negative Combinations by Location

The table below details the percent susceptibility of inpatient Gram-negative isolates to single agents and to the combination of antimicrobials indicated (number to the right of the arrow). Data are from 2015-2017.

MER = meropenem; TOB = tobramycin; PIPTAZ = piperacillin/tazobactam; CFPM = cefepime; CIP = ciprofloxacin

Population Number of Isolates

PIPTAZ -->

PIPTAZ + CIP

PIPTAZ -->

PIPTAZ + TOB

CFPM --> 

CFPM + CIP

CFPM --> 

CFPM + TOB

MER --> 

MER + CIP

MER --> 

MER + TOB

All inpatient/ED isolates 963 95% --> 99% 95% --> 99% 96% --> 98% 96% --> 99% 98% --> 99% 98% --> 100%
ICN 120 N/A 96% --> 100% N/A 97% --> 99% N/A 98% --> 100%
PICU & CICU 150 89% --> 99% 89% --> 100% 91% --> 94% 91% --> 97% 97% --> 99% 97% --> 100%
non-ICU 693 95% --> 99% 95% --> 99% 97% --> 99% 97% --> 99% 99% --> 100% 99% --> 100%