UCSF Benioff Children's Hospital Antimicrobial Susceptibility Gram-negatives Inpatient/ED

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N/A-testing NOT APPLICABLE to organism. CZOL-cefazolin, CTRX-ceftriaxone, CTAZ-ceftazidime, CFPM-cefepime, GEN-gentamicin, TOB-tobramycin, T/S-trimethoprim/sulfamethoxazole, CIP-ciprofloxacin, MER-meropenem, P/T-piperacillin-tazobactam

Values are % of strains testing susceptible to listed antibiotic. Unless indicated, results are for all inpatient/ED locations and culture sites.

Susceptibilities are based on data from 2019. Isolate numbers and 95% confidence intervals are provided to gauge precision of susceptibility estimate. 

Organism Total Isolates

CZOL

%S

(95% CI)

CTRX

%S

(95% CI)

CTAZ

%S

(95% CI)

CFPM

%S

(95% CI)

GEN

%S

(95% CI)

TOB

%S

(95% CI)

T/S

%S

(95% CI)

CIP

%S

(95% CI)

P/T

%S

(95% CI)

MER

%S

(95% CI)

Citrobacter freundii

9*

N/A

88

(52,99)

88

(52,99)

100

(66,100)

88

(52,99)

88

(52,99)

66

(30,93)

100

(66,100)

88

(52,99)

100

(66,100)

Enterobacter cloacae

37

N/A

N/A

N/A

86 (97)#

(67,94)

100

(91,100)

97

(86,100)

86

(71,95)

91

(78,98)

75

(59,88)

97

(86,100)

Escherichia coli

108

55**

(46,65)

87

(79,93)

87

(79,93)

88 (93)#

(81,94)

87

(79,93)

88

(81,94)

64

(55,74)

76

(68,84)

97

(92,99)

100

(97,100)

Klebsiella oxytoca

15*

6**

(0,32)

93

(68,99)

100

(78,100)

100

(78,100)

100

(78,100)

100

(78,100)

86

(60,98)

100

(78,100)

86

(60,98)

100

(78,100)

Klebsiella pneumoniae

40

62**

(46,77)

92

(80,98)

90

(76,97)

90 (100)#

(80,98)

92

(80,98)

92

(80,98)

72

(56,85)

87

(73,96)

90

(73,96)

100

(91,100)

Proteus mirabilis

10*

0**

(0,31)

90

(56,99)

100

(69,100)

100

(69,100)

100

(69,100)

100

(69,100)

70

(35,93)

100

(69,100)

100

(69,100)

100

(69,100)

Pseudomonas aeruginosa

34***

N/A

N/A

87

(72,97)

94

(80,99)

N/A

97

(85,99)

N/A

94

(80,99)

88

(73,97)

97

(85,99)

Serratia marcescens

14*

N/A

100

(77,100)

100

(77,100)

100

(77,100)

100

(77,100)

100

(77,100)

100

(77,100)

100

(77,100)

100

(77,100)

100

(77,100)

*When fewer than 30 isolates are reported, % susceptible may not reflect robust estimate of population susceptibility

**Reporting of Cefazolin susceptibility for E. coli, Klebsiella spp and Proteus is based on breakpoints for complicated infections - see outpatient E. coli susceptibilities for reporting based on uncomplicated UTI breakpoints

***Pseudomonas aeruginosa isolates do not include isolates from patients with cystic fibrosis.

# Number in parentheses represents the percentage of isolates both fully susceptible and susceptible-dose dependent to cefepime, for each organism. Susceptible-dose dependent isolates of Enterobacteriaceae are those with MIC 4 to 8 micrograms/mL for which a high dose of cefepime (anti-pseudomonal dosing) is anticipated to be active. Consult Pediatric ASP or ID for guidance on treating isolates reported as susceptible-dose dependent.