Outpatient, no comorbidities

Diagnosis Common Pathogens Drug(s) of First Choice Alternative Drug(s) Comments Expected Duration
(e.g. chronic heart, lung, liver, kidney disease, diabetes, ethanol use disorder, malignancy, asplenia)

Respiratory viruses

S.  pneumoniae

Mycoplasma pneumoniae

Chlamydia pneumoniae

H. influenza

Doxycycline

OR

Amoxicillin 1 g PO TID
 

Consider influenza testing and treatment with oseltamivir

Consider coverage for MRSA and/or Pseudomonas aeruginosa in patients with respiratory isolation of these organisms or receipt of parenteral
5 days

American Journal of Respiratory and Critical Care Medicine, Volume 200, Issue 7, 1 October 2019, Pages e45-e67, https://www.atsjournals.org/doi/full/10.1164/rccm.201908-1581ST