Outpatient, with comorbidities

Patient Population: Adult
Diagnosis Common Pathogens Drug(s) of First Choice Alternative Drug(s) Comments Expected Duration
(e.g. chronic heart, lung, liver, kidney disease, diabetes, ethanol use disorder, malignancy, asplenia)

Respiratory viruses

S.  pneumoniae

Mycoplasma pneumoniae

Chlamydia pneumoniae

H. influenza

Amoxicillin 1 g PO TID

PLUS Doxycycline


Levofloxacin 750 mg po qday


Consider influenza testing and treatment with oseltamivir

Consider coverage for MRSA and/or Pseudomonas aeruginosa in patients with respiratory isolation of these organisms or receipt of parenteral antibiotics within 90 days
5 days

American Journal of Respiratory and Critical Care Medicine, Volume 200, Issue 7, 1 October 2019, Pages e45-e67, https://www.atsjournals.org/doi/full/10.1164/rccm.201908-1581ST