Adult Outpatients: Skin and Soft-Tissue Infections: Mastitis


Doses provided in this table are for patients with normal renal and hepatic function. Click on drug link to go to dosing guidelines.  Some antimicrobials are restricted (ID-R).  Click on link for guidelines on obtaining authorization.


Common Pathogens

Drug(s) of First Choice

Alternative Drug(s)




S. aureus

Including MRSA becoming more frequent

Dicloxacillin 500 mg PO QID x 10-14 days


Cephalexin 500 mg PO QID x 10 -14 days


If patient with risk factors for MRSA:

TMP/SMX One DS tablet PO BID x 10-14 days


Clindamycin 300mg PO TID x 10-14 days

For mild PCN allergy:

Cephalexin 500 mg PO QID x 10-14 days


For severe PCN allergy:

Clindamycin 300 mg PO TID x 10-14 days 

If no abscess, increased frequency of nursing may hasten response.


If abscess, I & D required; discontinue nursing.


Doxycycline is active against MRSA but should not be used if patient is breastfeeding.