Adult Outpatients: Skin and Soft-Tissue Infections: Diabetic Foot Ulcer


Doses provided in this table are for patients with normal renal and hepatic function. Click on drug link to go to dosing guidelines.  Some antimicrobials are restricted (ID-R).  Click on link for guidelines on obtaining authorization.


Common Pathogens

Drug(s) of First Choice


Diabetic Foot Ulcer

Localized cellulitis without systemic signs or symptoms, no osteomyelitis 

S. aureus




Clindamycin 300 mg PO TID


If patient has been treated with antibiotics within the past month ADD:

LevofloxacinID-R: VASF 750 mg PO daily


Ciprofloxacin 500 mg PO BID   

While infections may be polymicrobial, they frequently respond to Gram-positive coverage alone.


Increasing rates of MRSA in the community may be a cause for failure to respond to initial therapy. 


Consider osteomyelitis especially if there is a failure to respond to therapy.


7-14 days of treatment is generally sufficient, duration should be based on clinical response.