Adult Outpatients: Respiratory Tract Infections: Pharyngitis


Doses provided in this table are for patients with normal renal and hepatic function. Click on drug link to go to dosing guidelines.  Some antimicrobials are restricted (ID-R).  Click on link for guidelines on obtaining authorization.


Common Pathogens

Drug(s) of First Choice

Alternative Drug(s)




Viral (EBV, rhinovirus, coronavirus, adenovirus etc)

Group A Streptococcus



Penicillin VK 250 mg PO TID-QID x 10 days

For severe PCN allergy:

Clindamycin 300 mg PO TID x 7-10 days

Most pharyngitis is viral thus antibiotics should not be used.


Treatment with PCN prevents rheumatic fever.


Treat documented Group A streptococcal infection confirmed by rapid strep. antigen test or culture or if 3 out 4 clinical criteria present.


Clinical Criteria: history of fever, tender anterior cervical adenopathy, absence of cough, tonsillar exudates.


Penicillin resistance has not been observed.