Adult Outpatients: Respiratory Tract Infections: Acute Exacerbation of Chronic Obstructive Pulmonary Disease


Doses provided in this table are for patients with normal renal and hepatic function. Click on drug link to go to dosing guidelines.  Some antimicrobials are restricted (ID-R).  Click on link for guidelines on obtaining authorization.


Common Pathogens

Drug(s) of First Choice

Alternative Drug(s)

Acute bacterial exacerbation of chronic bronchitis (COPD)

S. pneumoniae

H. influenzae

Moraxella catarrhalis

Doxycycline 100 mg PO BID X 10 days

Azithromycin 500 mg PO daily X 1 day; then 250 mg PO daily X 4 days