UCSF Benioff Children's Hospital Antimicrobial Susceptibility: Vancomycin Minimum Inhibitory Concentrations Among Staphylococcus aureus

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Some studies have associated higher minimum inhibitory concentrations (MICs) in Staphylococcus aureus with an increased likelihood of therapeutic failure. (Note: to date, studies do not indicate a strong relationship between vancomycin MIC and outcomes in Staphylococcus epidermidis, where a vancomycin MIC of 2 is common).

Pediatric Inpatient Vancomycin MIC Distribution for S. aureus

Vancomycin MIC (all S. aureus) 2014-2016
0.5 2.3% (8/344)
1 95.1% (327/344)
2 2.6% (9/344)
Vancomycin MIC (MRSA only)  
0.5 0% (0/76)
1 96.1% (73/76)
2 4% (3/76)