UCSF Benioff Children's Hospital Antimicrobial Susceptibility: Pediatric Inpatient/ED, Incidence-Weighted Gram-Negative Coverage By Drug

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The table below lists the % of Gram-negative organisms that tested susceptible to each listed drug or combination in 2014-2016.  The values incorporate the frequency with which the various organisms were isolated as well as their sensitivity to the drug; more commonly isolated organisms contribute more to the overall susceptibility results.  Results are based on standard methodology.

Population Number of Isolates Ceftriaxone Ertapenem Ceftazidime Cefepime Pip/tazo Meropenem
All isolates 853 78% (89%)* 86% (99%)* 92% 96% 96% 99%
ICN 99 83% (87%)*,** N/A 91% 97% 96% 100%
PICU & CICU 135 59% (82%)* 70% (98%)* 85% 92% 91% 95%
non-ICU 619 82% (91%)* 89% (99%)* 94% 97% 97% 99%

* Value in parenthesis is susceptibility if Pseudomonas and Acinetobacter are excluded

** For ICN, Cefotaxime susceptibility can be inferred from Ceftriaxone susceptibility; Gentamicin susceptibility among ICN Gram-negative isolates is 89% (94% if Pseudomonas and Acinetobacter are excluded)

 

Gram Negative Combinations by Location

The table below details the percent susceptibility of inpatient Gram-negative isolates to single agents and to the combination of antimicrobials indicated (number to the right of the arrow). Data are from 2014-2016.

MER = meropenem; TOB = tobramycin; PIPTAZ = piperacillin/tazobactam; CFPM = cefepime; CIP = ciprofloxacin

Population Number of Isolates

PIPTAZ -->

PIPTAZ + CIP

PIPTAZ -->

PIPTAZ + TOB

CFPM --> 

CFPM + CIP

CFPM --> 

CFPM + TOB

MER --> 

MER + CIP

MER --> 

MER + TOB

All isolates 853 96% --> 99% 96% --> 99% 96% --> 97% 96% --> 98% 99% --> 99% 99% --> 100%
ICN 99 N/A 96% --> 100% N/A 97% --> 98% N/A 100% --> 100%
PICU & CICU 135 91% --> 97% 91% --> 99% 92% --> 94% 92% --> 97% 95% --> 98% 95% --> 100%
non-ICU 619 97% --> 99% 97% --> 99% 97% --> 98% 97% --> 99% 99% --> 100% 99% --> 100%