Hospitalized Adults: Septic Shock, Source Unknown: Community Onset, No Recent Healthcare Exposures

PrintPrintPDFPDF

Doses provided in this table are for patients with normal renal and hepatic function. Click on drug link to go to dosing guidelines.  Some antimicrobials are restricted (ID-R).  Click on link for guidelines on obtaining authorization.

Diagnosis

Common Pathogens

Drug(s) of First Choice

Alternative Drug(s)

Comments

Septic Shock

Community onest, no recent healthcare exposure

Enterobacteriaceae

S. aureus

Streptococci spp.

Vancomycin

PLUS one of:

Piperacillin/

TazobactamID-R: SFGH 4.5 g IV q8h 

OR

Ertapenem 1 g IV daily

For severe PCN allergy:

Vancomycin

PLUS

Metronidazole 500 mg IV/PO q8h

PLUS one of

AztreonamID-R: SFGH 2 g IV q8h

OR

Tobramycin