Hospitalized Adults: Respiratory Tract Infections: Tuberculosis

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Doses provided in this table are for patients with normal renal and hepatic function. Click on drug link to go to dosing guidelines.  Some antimicrobials are restricted (ID-R).  Click on link for guidelines on obtaining authorization.

Diagnosis

Common Pathogens

Drug(s) of First Choice

Alternative Drug(s)

Comments

Suspected or documented active tuberculosis

Mycobacterium tuberculosis

Isoniazid 300 mg PO daily 

PLUS

Rifampin 600 mg PO daily 

PLUS

Pyrazinamide 25 mg/kg/day PO daily

PLUS

Ethambutol 15 mg/kg/day PO daily

PLUS

Pyridoxine (Vitamin B-6) 50 mg PO daily 

ID consultation strongly recommended for non-first-line regimens.

ID consultation is recommended.

 

Notify the SF Department of Public Health Tuberculosis Control at 415-206-8524 within one working day.

 

Guidelines for hospital discharge and follow-up and other resources at: http://www.sftbc.org/

 

Rifampin has numerous clinically significant drug interactions.  Medication lists should be reviewed for potential drug-drug interactions with rifampin.