Hospitalized Adults: Endocarditis: Prosthetic Valve

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Doses provided in this table are for patients with normal renal and hepatic function. Click on drug link to go to dosing guidelines.  Some antimicrobials are restricted (ID-R).  Click on link for guidelines on obtaining authorization.

Diagnosis

Common Pathogens

Drug(s) of First Choice

Comments

Prosthetic Valve

S. aureus

S. epidermidis

Vancomycin

PLUS

RifampinID-R: SFGH 300 mg PO q8h 

PLUS

Gentamicin 1 mg/kg/dose IV q8h for initial two weeks only

Single daily dose of gentamicin is not recommended

ID consultation is strongly recommended regarding choice and duration of therapy.

Rifampin has numerous clinically significant drug interactions.  Medication lists should be reviewed for potential drug-drug interactions with rifampin.

References:

Baddour LM, Infective endocarditis: diagnosis, antimicrobial therapy, and management of complications: a statement for healthcare professionals.... Circulation. 2005 Jun 14;111(23):e394-434.