Hospitalized Adults: Bone & Joint Infections: Septic Arthritis

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Doses provided in this table are for patients with normal renal and hepatic function. Click on drug link to go to dosing guidelines.  Some antimicrobials are restricted (ID-R).  Click on link for guidelines on obtaining authorization.

Diagnosis

Common Pathogens

Drug(s) of First Choice

Alternative Drug(s)

Comments

Septic Arthritis

 

S. aureus

Streptococci spp.

N. gonorrhoeae

Enterobacteriaceae (rarely)

Vancomycin

PLUS

Ceftriaxone1 g IV daily

For severe PCN allergy:

Vancomycin

PLUS ONE OF:

CiprofloxacinID-R: VASF 400 mg IV q12h

OR

Levofloxacin ID-R: VASF 500 mg IV daily

OR

AztreonamID-R: SFGH 2 g IV q8h if gonococcus is strongly suspected

Gram stain recommended to guide therapy.

Narrow coverage to microbiologically confirmed pathogens.