Gentamicin and Tobramycin Dosing in Neonates

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Use the charts below for dosing of Gentamicin and Tobramycin ONLY:

Age: Birth to 1 Month

Gestational Age (weeks) Dose Interval
<= 28 weeks 3.5 mg/kg/dose q 36 hours
29 - 34 3.5 mg/kg/dose q 24 hours
>= 35 weeks 5 mg/kg/dose q 24 hours*
*Use interval of q 36 hours for infants with HIE or significant asphyxia

 

Age: > 1 Month Postnatal

Corrected gestational age (weeks) Dose Interval
< 35

2.5

mg/kg/dose

q 12 hours
>= 35 q 8 hours*
*Renal or cardiac dysfunction, use 2.5 mg/kg/dose IV q12-24 hours

 

Monitoring:

< 35 weeks gestational age: order Peak and Trough with 4th dose

>= 35 weeks gestational age: order Trough only with 4th dose

HIE or significant asphyxia: Peak and Trough with 3rd dose