Adult Outpatients: Urogenital Infections: Syphilis

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Doses provided in this table are for patients with normal renal and hepatic function. Click on drug link to go to dosing guidelines.  Some antimicrobials are restricted (ID-R).  Click on link for guidelines on obtaining authorization.

Diagnosis

Common Pathogens

Drug(s) of First Choice

Alternative Drug(s)

Comments

Syphilis

Primary, Secondary, Early Latent

T. pallidum 

Benzathine penicillin G 2.4 MU IM X 1 dose

Doxycycline 100 mg PO BID X 2 weeks

Sexual partners must be treated.

 

Alternatives should only be used for penicillin-allergic patients because efficacy of these therapies has not been established.  Compliance with some of these regimens is difficult, and close follow-up is essential. 

 

 

Syphilis

Late Latent and Latent of Unknown Duration

T. pallidum 

Benzathine penicillin G 2.4 MU IM Q week X 3 doses 

Doxycycline 100 mg PO BID X 4 weeks