Adult Outpatients: Skin and Soft-Tissue Infections: Mastitis

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Doses provided in this table are for patients with normal renal and hepatic function. Click on drug link to go to dosing guidelines.  Some antimicrobials are restricted (ID-R).  Click on link for guidelines on obtaining authorization.

Diagnosis

Common Pathogens

Drug(s) of First Choice

Alternative Drug(s)

Comments

Mastitis

Postpartum 

S. aureus

Including MRSA becoming more frequent

Dicloxacillin 500 mg PO QID x 10-14 days

OR

Cephalexin 500 mg PO QID x 10 -14 days

 

If patient with risk factors for MRSA:

TMP/SMX One DS tablet PO BID x 10-14 days

OR

Clindamycin 300mg PO TID x 10-14 days

For mild PCN allergy:

Cephalexin 500 mg PO QID x 10-14 days

 

For severe PCN allergy:

Clindamycin 300 mg PO TID x 10-14 days 

If no abscess, increased frequency of nursing may hasten response.

 

If abscess, I & D required; discontinue nursing.

 

Doxycycline is active against MRSA but should not be used if patient is breastfeeding.