Adult Outpatients: Skin and Soft-Tissue Infections: Cellulitis

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Doses provided in this table are for patients with normal renal and hepatic function. Click on drug link to go to dosing guidelines.  Some antimicrobials are restricted (ID-R).  Click on link for guidelines on obtaining authorization.

Diagnosis

Common Pathogens

Drug(s) of First Choice

Comments

Cellulitis

β-hemolytic streptococci (most common)

 

S. aureus (less common) 

Cephalexin 500 mg PO QID

OR

Amoxicillin 500 mg PO TID

OR

Clindamycin 300 mg PO TID

If the patient does not respond to beta-lactam-based therapy consider adding TMP/SMX or doxycycline for MRSA coverage.

 

Clindamycin monotherapy provides reasonable coverage for both Group A strep and community-acquired MRSA however some isolates may be resistant. Please refer to hospital-specific antibiogram.

 

For cellulitis associated with an abscess treat for complicated abscess (see below).

 

7-10 days of therapy is generally adequate