Adult Outpatients: Gastrointestinal Infections: Diverticulitis

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Doses provided in this table are for patients with normal renal and hepatic function. Click on drug link to go to dosing guidelines.  Some antimicrobials are restricted (ID-R).  Click on link for guidelines on obtaining authorization.

Diagnosis

Common Pathogens

Drug(s) of First Choice

Comments

Diverticulitis

No signs of bowel perforation.

If bowel perforation, see Secondary Peritonitis on Inpatient Antibiotic Guidelines.

Enterobacteriaceae

Bacteroides fragilis

Enterococcus 

Amoxicillin/clavulanate

875 mg/125 mg PO BID

OR

MoxifloxacinID-R: SFGH 400 mg PO daily

OR the combination of:

Metronidazole 500 mg PO TID

PLUS ONE OF:

Ciprofloxacin 500 mg PO BID

OR

LevofloxacinID-R: VASF  500 mg PO daily

Duration of treatment should be until patient is afebrile for 3-5 days.

 

Surgical evaluation and follow up is advised.